Sequencher for Mac

Sequencher is a DNA Sequence analysis analyzing sequences in genomic and pharmaceutical companies including academic and government laboratories. It is used by life Science researchers in diverse DNA sequence analysis applications like the de novo gene sequencing, mutation detection, forensic human identification, systematics, and others. It features heterozygote and SNP detection and analysis, comparative sequencing, cDNA to Genomic DNA large gap alignment, it has support for confidence scores, ORF translation, GenBank that import and also restrict enzyme mapping. The Lion Compatible Sequencher is now Intel-native and is able to run on all versions of MacOS X from 10.5 to 10.7. The software can reference-guided alignments of more than 200 million bases using the Longer Reference Sequences Sequencher. It has a broad range of data import and export capabilities, which includes customizable GenBank Feature handling and specialized tools for Forensic mtDNA profiling. The software fully supports sequence data confidence values and it has powerful Reference Sequence and the Variance Table that could search SNPs.

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BioEdit

A biological sequence editor, BioEdit provide the basic functions needed for nucleic and protein sequence analysis, alignment, manipulation, and editing. It has a graphical interface for editing and sequence manipulation, with various editing options and it anchors alignment columns that helps in protecting fixed regions in alignment. This software can both automatically or manually annotate sequences using through features like exons, promoters and all other GenBank standard feature types. For synchronized hand alignment, BioEdit groups sequences into color-coded families and locks group members. It uses user-defined motif searching with the use of standard Prosite nomenclature which utilizes IUPAC characters to search for nucleic acid sequence, amino acid sequence, and text searches. It also has Rudimentary phylogenetic tree viewer that supports printing and node flipping, and RNA comparative analysis tools which includes potential pairings, covariation and mutual information analyses, and it also has amino acid translation which aligns protein-encoding nucleic acid sequences.

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